Indianapolis Times, Indianapolis, Marion County, 28 February 1951 — Page 17
. 28, 1951
aa. SY TERMS ition Wringer,
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WEDNESDAY, FEB. 28, 1051
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: THE INDIANAPOLIS TIMES PAGE 17
ill Vitamin Help Conquest 0f Leukemia?
U. of Wisconsin Scientists Discover
LONDON, Canada, Feb.
nescent satin clothing.
feet apart in a Canadian forest furnished this and other valuable information on what to wear to be the least—or the most—attrac-
‘Citrovorum Factor’ tive target for mosquitoes. - Dr. A. W. A. Brown, zoologist
By DAVID DIETZ or Sls of lie University at the University of Western Onof Wis sin have discovered a tario here, conducted the mosnew vitamin which promises to Suto attraction tests for Can's Defense Research Board
be of special aid in fighting the dread ‘cancer of the blood,” leu- ahd Department of Agriculture. Next to luminescent satins,
kemia. In leukemia, there is a wild Plain satins drew less than either
growth of immature white blood Proadcloths or crepes. Woven cells. Medical men have tried var-/nylon clothing was considerably jous chemical agents, such as less of a lure than cotton shirts aminopterin, to inhibit this. |and drill trousers. But the difficulty has been that, The drawing power was measthe substances which stop the/ured by counting the number of production of unnecessary white landings made by mosquitoes in blood ceNs also interfere with one and two-minute periods on normal tissue growth. {the dummies. The robots were
Report New Type Satin Clothing Foils Mosquitoes
Science Service
; 28--You can shop now to foil next summer’s ‘mosquitoes. To keep them from attacking you, buy lumi-
The pests are considerably less attracted to this material than to others tested for their drawing power. 'wo robot dummies, dressed to resemble men and placed six
two stainless steel tanks, containing 100 poufids of water electrically heated to body or other desired temperature, For most of the tests Dr. Brown dressed the dummies in a crepe jerkin and a felt shirt. A head was added if necessary to test the effect of exhaling different gases. Only one-tenth to one-quarter as many mosquitoes alighted on the dummy dressed in white as on the one dressed in black. This was true no matter how light it was during the tests. Green was less attractive than red or blue, and light reds and blues were less than half as attractive as the darker shades of the same colors. .
The hope is that the new vita-| min “will act as a check on the action, of aminopterin so that| healthy tissues are protected while the wild growth of the white blood cells is stopped. The vitamin has been given the cryptic name of the “citrovorum factor.” It is called “CF” for short. Its name needs explanation. Weren't Seeking Vitamins
The Wisconsin group of investigators that discovered vitamin CF weren't even looking for vitamins. They were studying amino acids, the chemical building blocks out of which proteins are constructed. : Bacteria require amino acids for growth just as do human beings. Because bacteria are easier to deal with than humans, the scientists were trying the effects of various amino acids on a type of bacteria known as the citrovorum. Their first discovery was that the citrovorum bacteria refused to grow.on a diet of pure amino acids but did very well when|’ liver extract was added to the bill of fare. Consequently they set about to find out what the essential factors were in the liver extract. Eventually they put their finger on two of them. ‘ One was folic acid, a wellknown component of the vitamin B complex. Folic acid, which also occurs in yeast and in green plants, now is being used successfully to treat certain types of anemia. Previously Unknown The other substance in the liver extract turned out to be a previously unknown substance which proved to be thousands of times more potent than folic acid in promoting the growth of the bacteria. It is this substance which now has been named the citrovorum factor or CF. ' Researches continuing at Wisconsin indicate that folic acid is converted into CF in the human body and that another vitamin, namely vitamin C or ascorbic acid, plays a role in this conver-
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