Indianapolis Times, Indianapolis, Marion County, 12 January 1950 — Page 40

: rand Opposite “w e— ,

| Medicine has inaugurated a more

Discovery Announced After Extensive

effective campaign against can-

. Dri ; y Vital Role in Births New Cancer Dive oS

3 I ed ~. Research by Cancer Institute four along. the fines of megleal edi 4 By JANE STAFFORD, Science Service Medical Writer | 2 L: and patient care,| -& WASHINGTON, Jan. 12—A vitamin and Is antivitamin play! § X Dean John D.| _“significiant” parts in the process by which babies are produced. VanNuys ay) "The discovery, announced here today by a team of National today, Cancer Institute scientists, was made on chicks, but probably is Dr. Edwin A.! true for reproduction in the human and-other species. Lawrence, has

: The vitamin is biotin, once antivitamin is called avidin. The Jargest concentration - of « naturthe yolk of egg. The avidin is found in egg white and In the part of the reproductive tract where the-egg albumen is formed, This i& no mere coincidence, the scientists now believe from their studies. - How It Works When they gave an estrogen, or female hormone, to sexually immature chicks, the biotin activity of their blood wis elevated about five-fold, . the scientists “found, Glving another hormone, progesterone, at the same time the: estrogen was given induces formation of avidin, or antibiotin, in the aviduct, but does not change thé. degree of elevation of the blood blotin activity; they report. Previously they had found that giving the two hormones simultaneously checks the growth

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believgd involved in cancer, Its

of the genital tract which is in-| ig

duced by giving estrogen alone. 7 When an egg is laid, an excess) of avidin is present, the scientists have also found. As ‘the egg Is incubated, the heat de-| stroys the avidin and ‘the chick develops. They are trying now to see whether they can alter the process of incubation by adding [either avidin or biotin. From such studies they hope to learn more about what is now a “challenging enigma.” that is, just

of reproduction. Both biotin and avidin have beer found in the eggs of all species so far examined, such as bird, frogs and turtles. Human and other mammalian eggs prob/ably. contain them also, but be-. cause of the small size of these egRs, the scientists have so far not been able to find either biotin

or avidin in them. They think .

‘they will when they develop bet-

ter techniques for isolating the substances from the tiny eggs. Latest. studies on blotin, avidin and reproduction are reported by Drs. Roy Hertz, ¥. GG. -Dhyse and William M. Tullner of the National Cancer Institute, U. 8. Public Health Service, in the scientific journal, Endocrinology. In

earlier studies Dr. W. H. Sebrell {of the National Institute of Health and Dr, R. M. Fraps of the Department of Agriculture worked with Dr. Hertz,

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University of school, of the leading centers on cancer in that area, Dr. Lawrence is considered a valuable addition to the IU staff, what Yunction the vitamin and its! antivitamin have in the process’

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been appointed as professor of| surgery and co-! ordinator of can«! cer treatment and research in connection with! the campaign. the staff of the

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