Decatur Daily Democrat, Volume 53, Number 171, Decatur, Adams County, 22 July 1955 — Page 8

PAGE EIGHT

100 Days Os Elaborate Tests On Polio Vaccine

INDIANAPOLIS HNS) — The manufacture of Salk polio vaccine requires 20 days, but IM days are used in the elaborate testing to assure safety. This five to one ratio, unique for precaution in the manufacture of any biologic, was disclosed In a report released by Eli Lilly and Company. of Indianapolis, today. The Lilly pharmaceutical house has provided approximately half of the. Salk vaccine used thus far. , and almost two thirds of al! that has been released since new testing standards were put into effect by the government. — ——- The report details the newstandard s for testing the safety of polio vaccine, and in general, covers all companies manufacturing i

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I »L A Lilly spokesman explained that because the production and i testing. of the vaccine is a highly complicated procedure, it never , before han been fully detailed. As ; a result, misunderstandings have arisen. ... When the tl. S. lujblic health service announced May 26 new , teats were being added after the . so called “Cutter incident” (some vaccine made by Cutter laboratories led to a suspicious increase in number of polio cases) confusion in the public mind was compounded because there was no dear explanation of what the orig- ! Inal tests were or what changes were being made. In connection with the If-page technical report, the Lilly spokesman disclosed that for his com--1 pany, little change had been required since it was “substantially meeting” the new requirements before they were imposed. The Lilly report notes: “Polio vaccine is really a mixture of three vaccines, each providing immunity against one of the tjiree main types of polio. Scientists have established that immunityagainst three types means immunity against all strains of polio —and there are The report then describes the testing methods used in its laboratories. ,

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“The production lota of virus of types I, 11 and 111 nre each kept separate .M. they are processed itito monovalent (single strain vacciues for subsequent mixing to make a trivalenl) three strains vaccine. The initial tests are per--1 formed on each type of virus be--1 fore the liquid which contains it : is subjected to thh inactivation process,” , The virus strength of the material is determined by observing t darnage to growing, monkey kidney cells, because this must be , known before the live virus cun be killed, or Inactivated. Hdt other safety tests are run first, to be sure the liquids containing the virus won’t give the patient some other infection. , A2l day test, using rabbka, determines the vaccine won’t ! give ; anyone ’ll’ virus. This is earrly experienced by humans since it results from the bite of an infected monkey, but the test is made 'just to be safe.” A seven day test is run to be sure no bacteria has contaminated the future vaccine, and other tests on guinea pigs and in test tubes are made against tuberculosis. These take 42 days each. Guinea pigs and rabbits are used because they are not susceptible to polio. The virus suspension is ready for inactivation. This is treatment with a formaldehyde solution which assures there will be no live virus remaining in the vaccine. It takes approximately 12 days, even though theoretically, killing requires only 72 hours.

THR DRCATTTR DAILY DEMOCRAT, DWCATUR, INDIANA

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A NEWSREEL photographer trying to approach the British delegation residence outside Geneva is barred by a determined looking Swiss guard, — -- |JaX«matM»»alZ

The most sensitive safety guard of all is the tissue culture test, which is run not once, but nine times in manufacturing each production lot of Salk vaccine. Two complete 21 - day culture tests are run on each monovalent strain, for a total of six. Two more tests are run after the three vaccines are mixed, and the ninth tissue culture test is taken when the vaccine has been placed in its final container. The report explains: “Preparations for the involve a remarkable technique called tissue culture. Uy this method the cells are actually grown outside the animal body. They are put into pint glass bottles containing a nourishing medium composed of 60 ingredients . . . During seven days of incubation, the cells multiply far beyond their original number and adhere In sheets to the insides of the glass bottles. “Twenty of these pint tissue culture bottles are used for testing each monovalent vaccine. The vac‘cine sample is added to fresh medium in the bottles. It is divided equally among the bottles and is incubated 14 days. “At the end of seven days there is a change medium and the bottles are examined under the microscope for evidence of live virus.” e ~ —■' ~ If live virus is found, the production lot will not be passed,'but as a rule, the kidney cells will appear to be undamaged. The re port notes that this is not accepted as giving the lot “a clean bill of health” but instead sub culturing tests are run also, fey incubating a sample of a sample in a fresh medium and studying the sub culture tubes for signs of cell damage."

I StiH the safety checking goes on. . Sterility tests, and safety tests • using monkeys and mice are taken. In addition to safety, the makers of Salk vaccine also must be sure ■ their product can stimulate the human body to grow its own fight- ■ ers against polio. Monkeys used for these 21 day tests also. A preservative is added, another i sterility test run. the vaccine is i bottledr-In the final container it receives another sterility test, an identity test and a tissue culture . or monkey safety test or both. It is then held in chill rooms . until the national institutes of , health approve it for distribution. Indianapolis Star's First Editor Dies INDIANAPOLIS (INS) — Funeral services were arranged today for the first news editor of the Indianapolis Star who died in his home at Manchester, Vt. James H. Furay. 75. foreign manager for United Press at the time of hist retirement in 1947, died Wednesday. He joined the Star as its first news editor when it was founded in 1903 and began a long association with Roy Howard, now chairman of the Scripps-Howard news--1 papers, who joined the Star as sports editor in 1904. CALLS CABINET (Continued from page One) a free country. He shared the view . of others who pointed out that Rus--sia knows far more about American military installations than the TJ. S. knows about hers. AIR FORCE (Continued from Page One) extremely reluctant to bring court martial proceedings where they can be avoided, said Wool’s resignation is being accepted “for the good of the service." Wool has been “confined to quarters’ at Wright - Patterson air force base in Dayton. Ohio, since the Lev investigation began nearly three months ago. CRAVENS IS (Continued from Page One) naire associates of Governor George N. Craig. ° If Cravens is appointed chairman. many political observers believe it would be an act of the palace guard seeking to kick the Franklin man upstairs and out of the contest for governor. In the event Cravens turns down the ABC chairmanship, political observers felt that Glenn W. Funk the ABC prosecutor was the most likely choice to take over the Owen vacancy. NOTICE OF- ADMINISTRATION In the - plncuit Count of Adams County, Indiana. Notice ife> hereby given that Elsie May S’limyions was on the lath day of July, 19s>5 Appointed: AdwiiniHtratrlx of the estate of Muses K rSlmnians. ail»o known as William 8. Simmons. also known "its Sherman Simmons deceased. All persons having claims agaipst said estate, whether on not now due, nmst file tilie oame in said Court within six months from the date of the first publication of this notice or said claims will :he forever 'barred. Hated at Decatur, Indiana, this IDtih day of July, EDWARD F.' JABERG Clerk of the Circu.it Court ' for iAdams Counity, Indiana. Me*h>l & Mehl Goshen, Indiana, Attorney. July 22-29, A'llg. 5 NOTICE TO BIDDERS Notice js hereby given that the Boord of School Trustees of the School City of Decatur, Ad'ams County, Indiana, will up to the hour at 4; 00 P. M. on Monday, August 1, 1955 at the office e< the City ; -mtpkrinwtdewt- -rtf Sehoofet-revem sealed blds for the following: 106 steel movable deaks 6 Kindergarten tables 9 40 Kindergarten chairs 12 teacher's desks 12 teacher's chairs Comp-lete specifications are available at the above mentioned office. Each bid to be accompanied by a certilfled ohleek payabbe to the Board of School Trustees in an anii>unJf“eßWLy'aleuit to five ipercent of said Jintl. \ Bids- hmst Ata submitted on Form 95 as hreerlTbed by the State Board of AcvotanWs, which forms may be secured it the office of the City Superintendent of Hchools. The Board reserves the right to reject any or all blds. By order of the Board of School Trustees, this 2.lst day oL-J-u4y, 1956. N Board of School Trustees , of School City of Decatur. Indiana. By: Everett Hutker, Secretary JUly 22-39

Strike Set Monday For Indiana Plants Four Perfect Circle Plants Threatened RICHMOND, Ind. (INS) —A strike of four Indiana plants ot the Perfect Circle Corporation has been set to begin Monday. > Negotiations for a new contract were broken off and no further | meetings were planned before the present contract expires at midnight Sunday, c_ •' CIO United Auto Workers representatives said that a strike vote authorised the work stoppage if no contract fa in force. The company has two plants in Richmond, and one each in Hagerstown and New Castle, where a total of 2.000 are employed. Company representatives said that the “full union shop" provision was the principal source of contention. A company spokesman said Perfect Circle had gone through a two month strike In 1948 rather than agree to a closed shop. UAW officials said they are asking a guaranteed annual employment plan, full union shop, 20 cent hourly package wage increase, compulsory arb'fratlon and increased retirement and insurance benefits. Two Men Chosen As Guest Replacements INDIANAPOLIS (INS) —Two men were burned today from a list of 40 conductors as guest replacements with the Indianapolis Symphony orchestra. At least four more conductors will be chosen to join Victor Ales-

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